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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP1CA
All Species:
40.61
Human Site:
S48
Identified Species:
59.56
UniProt:
P62136
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P62136
NP_001008709.1
330
37512
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Chimpanzee
Pan troglodytes
XP_001151893
326
36742
L49
F
L
S
Q
P
I
L
L
E
L
E
A
P
L
K
Rhesus Macaque
Macaca mulatta
XP_001117941
427
47327
S145
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P62137
330
37522
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Rat
Rattus norvegicus
P62138
330
37494
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006190
323
36981
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Frog
Xenopus laevis
Q7SZ10
323
36919
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Zebra Danio
Brachydanio rerio
NP_997875
332
37590
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48461
327
37351
E52
L
S
Q
P
I
L
L
E
L
E
A
P
L
K
I
Honey Bee
Apis mellifera
XP_392943
329
37410
S48
K
S
R
E
I
F
L
S
Q
P
I
L
L
E
L
Nematode Worm
Caenorhab. elegans
P48727
333
37773
E53
L
S
Q
P
I
L
L
E
L
E
A
P
L
K
I
Sea Urchin
Strong. purpuratus
XP_791029
330
37658
S48
K
S
R
E
I
F
L
S
Q
P
N
L
L
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P22198
316
35745
N48
E
I
F
L
Q
Q
P
N
L
L
E
L
E
A
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48486
322
36548
N48
E
V
F
L
S
Q
P
N
L
L
E
L
E
A
P
Baker's Yeast
Sacchar. cerevisiae
P32598
312
35889
L52
F
I
K
Q
P
I
L
L
E
L
E
A
P
I
K
Red Bread Mold
Neurospora crassa
Q9UW86
308
35549
S48
K
A
R
E
I
F
I
S
Q
P
I
L
L
E
L
Conservation
Percent
Protein Identity:
100
95.1
75.1
N.A.
N.A.
99.6
100
N.A.
N.A.
90
90.3
89.7
N.A.
87.5
89.3
90.3
89.3
Protein Similarity:
100
95.4
76.8
N.A.
N.A.
100
100
N.A.
N.A.
93.3
93.3
94.8
N.A.
92.1
93
94.2
94.5
P-Site Identity:
100
6.6
100
N.A.
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
26.6
100
26.6
93.3
P-Site Similarity:
100
20
100
N.A.
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
46.6
100
46.6
93.3
Percent
Protein Identity:
N.A.
72.4
N.A.
73.3
80.6
81.5
Protein Similarity:
N.A.
83
N.A.
85.7
87.5
88.1
P-Site Identity:
N.A.
6.6
N.A.
6.6
6.6
86.6
P-Site Similarity:
N.A.
20
N.A.
20
26.6
100
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
13
13
0
13
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
13
0
0
63
0
0
0
13
13
13
25
0
13
63
0
% E
% Phe:
13
0
13
0
0
63
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
13
0
0
75
13
7
0
0
0
57
0
0
7
13
% I
% Lys:
63
0
7
0
0
0
0
0
0
0
0
0
0
13
13
% K
% Leu:
13
7
0
13
0
13
82
13
25
25
0
75
75
7
63
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
13
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
13
13
0
13
0
0
63
0
13
13
0
13
% P
% Gln:
0
0
13
13
7
13
0
0
63
0
0
0
0
0
0
% Q
% Arg:
0
0
63
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
69
7
0
7
0
0
63
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _